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目的 :研究干扰素与病毒唑联合治疗慢性丙型肝炎疗效及干扰素抗体的影响。方法 :观察组 2 0例采用干扰素 α2b 3MvTiwIH +病毒唑 10 0 0mgQdpo连用 2 4周 ;对照组 3 2例采用干扰素 α2b 3MvTiwiH连用 2 4周。停药后观察 2 4周比较疗效并检测干扰抗体。结果 :观察组完全应答率为 5 0 % ,明显高于对照组 18.7% ;复发率为 2 5 .0 %低于对照组 5 6.3 % (P <0 .0 1)。无反应率均为 2 5 .0 %。且复发与干扰素抗体尤其是中和抗体有关。结论 :观察组疗效优于对照组 ,复发与干扰素抗体尤其是中和抗体有关。
Objective: To investigate the curative effect of interferon and ribavirin in the treatment of chronic hepatitis C and the influence of interferon antibody. Methods: Twenty patients in the observation group were given interferon α2b 3MvTiwIH + ribavirin 10 0mg Qdpo for 24 weeks. In the control group, 32 patients were treated with interferon α2b 3MvTiwiH for 24 weeks. Observed after stopping 24 weeks efficacy and detection of interfering antibodies. Results: The complete response rate of the observation group was 50%, which was significantly higher than that of the control group (18.7%). The recurrence rate was 25.0% lower than that of the control group (6.3%, P <0.01). No response rate was 25.0%. Relapse is associated with interferon antibodies, especially neutralizing antibodies. Conclusion: The observation group is better than the control group, relapse and interferon antibodies, especially neutralizing antibodies.