前有文献报道疟原虫裂殖子入侵宿主红细胞与红细胞上的涎糖蛋白(Sialoglycoprotein)有关,缺乏主要涎糖蛋白成分即血型糖蛋白A的红细胞对恶性疟原虫入侵具有一定的抗性。作者用不同的人红细胞和经过处理人工改变了膜上涎糖蛋白所得的红细胞对这问题作了进一步研究。结果表明:缺少血型糖蛋白A的红细胞(En(a-))和缺少血型糖蛋白B(S-s-U-和S-s-U+)的红细胞对恶性疟原虫裂殖子入侵呈现明显的抗性;而用胰蛋白酶或胰凝乳蛋白酶处理正常红细胞也能减少裂殖子的侵入。作者根据上述酶处理后除去了血型 Previous reports in the literature that the malaria merozoites invade host erythrocytes and erythrocytes on the expression of sialoglycoprotein (Sialoglycoprotein), the lack of the main sarcomeric glycoprotein glycoprotein A red blood cells have some resistance to Plasmodium falciparum invasion. The authors further investigated this issue with different human erythrocytes and red blood cells that have been artificially altered by oncosis glycoproteins. The results showed that erythrocytes lacking glycophorin A (En (a-)) and erythrocytes lacking glycophorin B (SsU- and Ss-U +) showed obvious resistance to P. falciparum merozoite invasion. However, Protease or chymotrypsin treatment of normal red blood cells can also reduce the invasion of merozoites. The authors removed the blood type after the above enzyme treatment