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目的比较应用左氧氟沙星联合泮托拉唑和阿莫西林(观察组)与应用甲硝唑联合泮托拉唑和阿莫西林(对照组)治疗消化性溃疡及根除幽门螺杆菌感染的疗效。方法经胃镜检查证实为消化性溃疡及尿素酶试验检测HP证实为阳性的54例患者,随机分为观察组及对照组各27例,疗程7 d。经一疗程治疗后,比较两组疗效。结果 HP根除,观察组为88.9%,对照组为70.4%,差异有统计学意义(P<0.05);溃疡愈合总有效率,观察组为96.3%,对照组为92.6%,差异无统计学意义(P>0.05)。结论 HP耐药菌株日益增多,左氧氟沙星联合泮托拉唑和阿莫西林三联疗法是一种安全、疗效高,耐受性好的根除HP感染,促进溃疡愈合的理想方法之一。
Objective To compare the efficacy of levofloxacin plus pantoprazole and amoxicillin (observation group) with metronidazole and pantoprazole and amoxicillin (control group) in the treatment of peptic ulcer and helicobacter pylori infection. Methods Fifty-four patients confirmed by gastroscopy as peptic ulcer and urease test positive for HP were randomly divided into observation group and control group with 27 cases each for 7 days. After a course of treatment, the two groups were compared. Results HP eradication, the observation group was 88.9%, the control group was 70.4%, the difference was statistically significant (P <0.05); the total effective rate of ulcer healing, the observation group was 96.3%, the control group was 92.6%, the difference was not statistically significant (P> 0.05). Conclusion The number of HP resistant strains is increasing day by day. Levofloxacin combined with pantoprazole and amoxicillin triple therapy is a safe, effective and well tolerated HP infection, which is one of the ideal ways to promote the healing of ulcer.