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胆囊结石是外科最常见的疾病之一,胆囊切除术一直被视为本病最有效的治疗方法,大肠癌是胃肠道中常见的恶性肿瘤,随着饮食结构的改变,在胃癌,食管癌发病率下降的同时,大肠癌的发病率却逐年升高。但大肠癌的病因尚未明确,可能与饮食习惯、遗传素质、大肠腺瘤病、慢性粘膜炎症等有关。1978年Ekboma首次报道胆囊结石、胆囊切除术可增加大肠癌的发病率后[1],引起人们对两者之间关系的关注。但相反的报道也存在,可能与各研究中大肠癌的诊断时间、检出率及胆囊切除的适应证掌握等因素不同有关[2]。胆囊结石、胆囊切除术是否会增加大肠癌的危险性,迄今尚有争议。本文查阅了近几年国内外文献报道,就有关问题做一综述。
Cholecystolithiasis is one of the most common surgical diseases. Cholecystectomy has been regarded as the most effective treatment for this disease. Colorectal cancer is a common malignant tumor in the gastrointestinal tract. With the change of dietary structure, in the pathogenesis of gastric cancer and esophageal cancer The rate of decline, while the incidence of colorectal cancer has increased year by year. However, the etiology of colorectal cancer is not yet clear, and may be related to diet, genetic predisposition, colorectal adenosis, chronic mucosal inflammation and so on. Ekboma first reported gallstones in 1978, and cholecystectomy increased the incidence of colorectal cancer [1], arousing public concern over the relationship between the two. But the opposite report also exists, may be related to the study of colorectal cancer diagnosis time, detection rate and indication of cholecystectomy and other factors related to different [2]. Gallstone, cholecystectomy will increase the risk of colorectal cancer has so far been controversial. This article refers to the domestic and foreign literature reports in recent years, to make a summary of the relevant issues.