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目的：研究反流性食管炎（ＲＥ）患者酸反流和胆汁反流的发生情况以及同时检测这两种反流的临床意义。方法：ＲＥ患者１５例及健康志愿者１２例，应用便携式ｐＨ监测仪及胆汁监测仪同步检测食管２４ｈｐＨ变化及胆汁反流情况。结果：ＲＥ组食管酸暴露时间比对照组显著增加，而ｐＨ＞８总时间百分比与对照组相似。食管胆汁反流用胆红素吸收值≥０．１４的时间百分比表示，ＲＥ组较对照组明显增高。６６．７％的ＲＥ患者存在酸及胆汁混合反流。结论：胆汁反流与酸反流同样常见于ＲＥ患者，在胃食管反流病的发生中起一定作用。同步动态检测食管内ｐＨ及胆汁变化对ＲＥ的诊断有重要意义
Objective: To study the occurrence of acid reflux and bile reflux in patients with reflux esophagitis (RE) and the clinical significance of simultaneous detection of these two reflux. Methods: Fifteen patients with RE and 12 healthy volunteers were enrolled in this study. The changes of 24hpH and bile reflux were detected simultaneously by portable pH monitor and bile monitor. RESULTS: Esophageal acid exposure time in RE group was significantly higher than that in control group, while the percentage of total pH> 8 was similar to that in control group. Esophageal bile reflux with bilirubin absorption value ≥ 0.14 percentage of time, RE group was significantly higher than the control group. 66.7% of patients with RE have mixed acid and bile reflux. Conclusions: Bile reflux and acid reflux are also common in patients with RE and play a role in the pathogenesis of gastroesophageal reflux disease. Simultaneous dynamic detection of esophageal pH and bile changes is of great significance for the diagnosis of RE