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目的探讨宫颈原发性Müllerian腺肉瘤的临床病理特征,提高对该瘤的认识。方法对4例发生于宫颈的Müllerian腺肉瘤进行光镜、免疫组化标记检查,并复习临床资料及相关文献。结果临床上患者以阴道不规则出血为主要症状。镜下肿瘤由良性腺上皮成分和肉瘤性间质成分组成;腺体常扩张,异型性较明显的间质成分突入腺腔内形成息肉状结构,腺体周围间质成分比较密集,围绕腺体形成“袖套样”结构;核分裂象分布不均(1～15个/10 HPF)。免疫表型没有特异性。结论宫颈原发性Müllerian腺肉瘤是一种罕见的肿瘤,诊断主要依靠组织形态学特征,免疫组化标记主要用于确定异源性成分及与其他肿瘤的鉴别。
Objective To investigate the clinicopathological features of primary Müllerian adenosarcoma and to improve the understanding of the tumor. Methods Four cases of Müllerian adenosarcoma in the cervix were examined by light microscopy and immunohistochemistry. Clinical data and related literatures were reviewed. Results Clinical patients with irregular vaginal bleeding as the main symptom. Microscopic tumor consists of benign glandular epithelial components and sarcomatoid interstitial components; often dilated glands, atypia more obvious interstitial components into the glandular cavity to form a polypoid structure, the gland around the interstitial components more dense around the gland formation “Sleeve-like” structure; mitotic figures are unevenly distributed (1-15 / 10 HPF). Immunophenotype is not specific. Conclusions Cervical primary Müllerian adenosarcoma is a rare tumor. The diagnosis mainly depends on histological features. The immunohistochemical markers are mainly used to identify the heterologous components and to distinguish them from other tumors.