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通过对慢性疲劳大鼠学习记忆情况的测定，结合对大鼠脑组织能荷的测定，研究疲劳后记忆的改变，并探讨中药元气精华抗疲劳和改善记忆的作用及药效学机制。结果：中药治疗组学习成绩提高比模型对照组和空白对照组有明显提高，而与人参皂甙组无统计学差异，说明中药能改善大脑疲劳状态，提高学习记忆能力，效果与人参皂甙组接近。中药治疗组学习中出错次数比模型对照组和人参皂甙组明显减少，说明中药制剂元气精华能改善大鼠记忆巩固程度，且效果优于人参皂甙。同时，模型对照组的能荷值明显低于安静对照组的能荷值，说明大鼠经过一定量的负荷运动后，其脑组织中ＡＭＰ氧化磷酸化减少，细胞内高能磷酸化合物分解增加，ＡＴＰ含量减少，脑能量耗竭，提示大鼠处于疲劳状态。中药治疗组脑能荷值比模型对照组有明显提高，而与人参皂甙组无统计学差异，说明中药制剂元气精华能降低脑代谢率，使脑能量代谢状态得以改善，效果与人参皂甙组接近。研究结果表明：大强度训练会影响大脑能量代谢，使智力降低；而中药制剂元气精华可以改善大脑能量代谢，提高智力。
Through the study of learning and memory in rats with chronic fatigue, combined with the measurement of energy load in brain tissue of rats, the change of memory after fatigue was studied. The anti-fatigue and memory-improving effect and pharmacodynamic mechanism of Chinese herbal medicine’s Qi-essence were also discussed. Results: Compared with the model control group and the blank control group, the improvement of academic performance in the traditional Chinese medicine treatment group was significantly improved, but no significant difference with the ginsenoside group, indicating that Chinese medicine can improve the fatigue state of the brain and improve the learning and memory ability, and the effect is close to that of the ginsenoside group. Chinese medicine treatment group learning errors than the model control group and the ginsenoside group was significantly reduced, indicating that the Chinese medicine preparation can improve the degree of memory consolidation, and the effect is better than ginsenosides. Meanwhile, the energy charge of the model control group was significantly lower than that of the quiet control group, indicating that after a certain amount of exercise, the oxidative phosphorylation of AMP in the brain decreased, the breakdown of intracellular high-energy phosphate compounds increased, and ATP Reduced content, brain energy depletion, suggesting that rats are in a state of fatigue. Chinese medicine treatment group than the model group, the brain charge increased significantly, but no significant difference with the ginsenoside group, indicating that the Chinese medicine preparation can reduce the metabolic rate of brain energy metabolism of brain energy can be improved, the effect of close to the ginsenosides group . The results show that: intensive training will affect the energy metabolism of the brain, so that mental retardation; and herbal essence can improve energy metabolism, improve intelligence.