目的：了解类风湿关节炎（ＲＡ）血清、滑液和滑膜组织中转化生长因β１（ＴＧＦβ１）、细胞间粘附分子１（ＩＣＡＭ１）及细胞间粘附分子３（ＩＣＡＭ３）的变化。方法：采用ＥＬＩＳＡ及ＡＢＣ免疫组化方法检测ＲＡ患者血清、滑液和滑膜中ＴＧＦβ１、ＩＣＡＭ１和ＩＣＡＭ３的浓度和阳性程度。结果：ＲＡ血清中ＴＧＦβ１含量较低，而ＩＣＡＭ１含量明显升高，ＩＣＡＭ３含量正常，滑液中ＩＣＡＭ３含量低于血清含量。ＲＡ血清中ＴＧＦβ１含量与ＩＣＡＭ１含量呈中度负相关，与ＩＣＡＭ３含量无显著相关。在ＲＡ滑膜中巨噬细胞、滑膜衬里细胞和成纤维细胞ＴＧＦβ１染色阳性，巨噬细胞、滑膜衬里细胞、成纤维细胞和血管内皮细胞ＩＣＡＭ１染色阳性。结论：ＴＧＦβ１和ＩＣＡＭ１参与了ＲＡ的发生和发展过程，在ＲＡ慢性炎症中，ＩＣＡＭ１对炎细胞转移并聚集于滑膜可能有重要作用，ＲＡ外周血ＴＧＦβ１浓度减低伴随ＩＣＡＭ１浓度的增加。 Objective: To investigate the expressions of transforming growth factor β1 (TGFβ1), intercellular adhesion molecule1 (ICAM1) and intercellular adhesion molecule3 (ICAM) in rheumatoid arthritis (RA) serum, synovial fluid and synovial tissue, 3) changes. Methods: The concentrations of TGFβ1, ICAM1 and ICAM3 in serum, synovial fluid and synovium of RA patients were detected by ELISA and ABC immunohistochemistry. Results: The content of TGFβ1 in RA serum was lower, the content of ICAM1 was significantly increased, the content of ICAM3 was normal, the content of ICAM3 in synovial fluid was lower than that in serum. RA serum TGFβ1 content and ICAM 1 content was moderately negative correlation, and ICAM 3 content was not significantly correlated. In RA synovium, macrophages, synovial lining cells and fibroblasts TGFβ1-positive, macrophages, synovial lining cells, fibroblasts and vascular endothelial cells ICAM 1 staining. Conclusion: TGFβ1 and ICAM 1 are involved in the pathogenesis and progression of RA. In RA chronic inflammation, ICAM-1 may play an important role in the metastasis of inflammatory cells and accumulation in the synovium. The decrease of TGFβ1 in RA peripheral blood accompanied with ICAM-1 concentration Increase.