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目的:研究乳腺癌患者干细胞标记物ALDH1与乳腺癌的相关性。方法:通过免疫组化的方法研究58例乳腺癌患者ALDH1表达与肿瘤特点的相关性。结果:乳腺癌患者31%ALDH1表达阳性,69%表达阴性;ALDH1表达与病理学分级相关;与ER、PR阴性表达相关;与其他诸如年龄、淋巴结数目、ki-67表达等无明显相关性。结论:乳腺癌干细胞标记物ALDH1在乳腺癌患者中具有高表达,与乳腺癌肿瘤细胞的一些特点具有相关性,但仍需要一些研究进一步阐明他们与乳腺癌之间的关系。
Objective: To investigate the correlation between stem cell marker ALDH1 in breast cancer and breast cancer. Methods: The expression of ALDH1 in 58 cases of breast cancer was studied by immunohistochemistry. Results: 31% of patients with breast cancer had positive ALDH1 expression and 69% negative expression. ALDH1 expression was correlated with pathological grade, ER and PR negative expression, but not with age, lymph node number and ki-67 expression. CONCLUSIONS: The breast cancer stem cell marker ALDH1 is highly expressed in breast cancer patients and correlates with some characteristics of breast cancer cells. However, some studies are needed to further elucidate their relationship with breast cancer.