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目的探讨地方性砷中毒对机体免疫功能的远期影响,为砷中毒病区居民的预防和治疗提供科学依据。方法采用整群抽样和典型调查相结合的方法进行现场调查,将改水5年后的砷中毒病区调查者分为轻、中、重度病例组和内对照组,非病区调查者为外对照组;对调查者的免疫功能指标免疫球蛋白G(IgG)和溶菌酶(LSZ)进行测定,采用SPSS 13.0软件对数据进行统计分析。结果调查5个组共252人,所选择的病区村5年前已实施改水,水砷含量符合国家标准(≤0.05 mg/L),各组尿砷含量差异无统计学意义(H=2.698,P>0.05);各组IgG含量差异有统计学意义(H=52.923,P<0.01),外对照组IgG均数为11.16 g/L,含量明显高于其他组(P<0.05),其他组间比较差异无统计学意义(P>0.05);各组溶菌酶水平差异有统计学意义(H=34.998,P<0.01),外对照组溶菌酶水平为13.57μg/ml,明显高于其他组(P<0.05),其他组间比较差异无统计学意义(P>0.05)。结论地方性砷中毒患者饮用低砷水5年后砷对机体免疫功能的影响仍然存在,砷中毒病区在加大除砷改水力度的同时,应加强居民身体状况的监测。
Objective To investigate the long-term effects of endemic arsenism on immune function and to provide a scientific basis for the prevention and treatment of residents with arsenic poisoning. Methods The method of cluster sampling and typical survey was used to carry out on-the-spot investigation. The arsenic poisoning patients who changed water five years later were divided into mild, moderate and severe cases and control group. Control group. Immunoglobulin G (IgG) and lysozyme (LSZ) of immunosuppressants were measured and the data were analyzed by SPSS 13.0 software. Results A total of 252 patients in 5 groups were investigated. The selected ward villages had been rehabilitated five years ago. The arsenic content of the water met the national standard (≤0.05 mg / L), and there was no significant difference in the urinary arsenic content between the groups (H = 2.698, P> 0.05). The IgG content in each group was significantly different (H = 52.923, P <0.01). The IgG in the external control group was 11.16 g / L, There was no significant difference among the other groups (P> 0.05). The levels of lysozyme in each group were significantly different (H = 34.998, P <0.01), while the level of lysozyme in the external control group was 13.57μg / ml Other groups (P <0.05), no significant difference between the other groups (P> 0.05). CONCLUSIONS: After 5 years of drinking low-arsenic water in patients with endemic arsenism, the effects of arsenic on immune function still exist. As arsenism in arsenic poisoning area, efforts should be made to improve the arsenic-removing water while strengthening the monitoring of residents’ physical status.