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盐酸阿米洛利(Amiloride Hydrochlor)又名盐酸氨氯吡咪(以下简称A),国外商品名为Midamor,其结构与氨苯喋啶相似,具有保钾排钠作用强、起效快、作用持续时间长,副反应轻,用量少等优点,且有降压及改善心功能的作用。本品为国外最广泛使用的保钾利尿药。我国杭州民生药厂已合成该品,填补国内空白,即将投放市场。现将该品的药理及其复方制剂的临床应用等综述如下: 药理作用对尿电解质的影响 A作用于远曲小管,影响Na_-~+-K~+、Na_-~+-H_-~+交换,抑制Na~+重吸收,被动性
Amiloride hydrochloride (Amiloride Hydrochlor), also known as amiloride hydrochloride (hereinafter referred to as A), the foreign trade name is Midamor, its structure and similar to triamterene, potassium with a strong role in sodium, rapid onset, the role Long duration, light side effects, less dosage and other advantages, and antihypertensive and improve cardiac function. This product is the most widely used potassium abroad diuretics. China Minsheng Pharmaceutical Factory in Hangzhou has synthesized the product, to fill the domestic blank, to be put on the market. Now the product pharmacology and clinical application of compound preparations, etc. are summarized as follows: Pharmacological effects on urinary electrolytes A role in the distal convoluted tubules, affecting Na ~ - + -K ~ +, Na_- ~ + -H_- ~ Exchange, inhibit Na ~ + reabsorption, passive