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青霉素G治疗早期钩端螺旋体病(简称钩体病)疗效显著。但首剂青霉素G后,部分病例可发生赫氏反应(JHR),其中个别病例可演变为肺弥漫性出血(PDH)致死。为了预防JHR的发生,我们于1980～1981年夏秋,在眉山县,对未接种过钩体苗苗,入院前未经抗生素治疗,实验室证实的45例感染中毒型钩体病(男21例,女24例,年龄9～61岁,病程6～7日2例,5日内43例)进行了临床研究。 采取前瞻性双盲法,随机分为:(一)JHR预防组 (称预防组)20例,每例以青霉素 G 40万单位肌注,
Penicillin G treatment of early leptospirosis (leptospirosis) significant effect. However, the first dose of penicillin G, in some cases can occur Heath reaction (JHR), of which individual cases can evolve into diffuse hemorrhagic lung (PDH) lethal. In order to prevent the occurrence of JHR, in the summer of 1980 ~ 1981, in Meishan County, we did not receive the leptospira vaccine before hospitalization, and we did not get the antibiotic treatment before admission. We confirmed 45 cases of leptospirosis (21 males , 24 females, aged 9 to 61 years old, duration of 6 to 7 days in 2 cases, 5 days in 43 cases) were studied. To take a prospective double-blind method, were randomly divided into: (a) JHR prevention group (prevention group) 20 cases, each case of penicillin G 400 000 units intramuscular injection,