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应用免疫组化ＬＳＡＢ法测定３３例胰腺癌及８例正常胰腺组织中ｒａｓＰ２１的表达。结果表明：３３例胰腺癌中２０例（６０．６％）Ｐ２１有过度表达，正常胰腺组织全部为阴性。Ｐ２１过度表达与胰腺癌的分化程度及浸润程度密切相关（Ｐ＜０．０５）。Ｐ２１过度表达与病人二年生存率呈负相关性，统计学上检验有显著性。检测ｒａｓＰ２１对正确评价胰腺癌的预后有一定的指导意义。
The expression of rasP21 in 33 cases of pancreatic cancer and 8 cases of normal pancreas was determined by immunohistochemical LSAB method. The results showed that P21 was overexpressed in 20 (60.6%) of 33 pancreatic cancers, and all normal pancreas tissues were negative. The overexpression of P21 was closely related to the degree of differentiation and infiltration of pancreatic cancer (P<0.05). There was a negative correlation between P21 overexpression and the patient’s two-year survival rate, which was statistically significant. The detection of rasP21 has a certain guiding significance for the correct evaluation of the prognosis of pancreatic cancer.