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目的利用Meta分析观察复方玄驹胶囊治疗不育症的疗效。方法检索Cochrane图书馆,Pubmed数据库,中国生物医学文献数据库,CNKI数据库,VIP数据库,万方数据库,纳入复方玄驹胶囊治疗不育症的随机对照治疗(RCT),并进行方法学质量评价,采用RevMan5.3软件进行统计分析,并发表偏倚评估和敏感性分析。结果 9篇RCT文献纳入本项研究,累计病例1199例。Meta分析结果显示:复方玄驹胶囊在改善和提高A级精子率[WMD=1.35,95%CI(-6.36,9.07),P=0.73]、(a+b)级精子率[WMD=6.54,95%CI(-17.03,30.11),P=0.59]、精子密度[WMD=3.80,95%CI(-4.23,11.82),P=0.35]、精子活率[WMD=-68.66,95%CI(-12.13,-5.19),P<0.01]、显效率[RR=0.79,95%CI(0.51,1.23),P=0.30]和总有效率[RR=0.86,95%CI(0.70,1.05),P=0.13]方面并无优势,而在改善正常形态百分率[WMD=9.00,95%CI(0.59,17.40),P=0.04]方面优于对照组。结论复方玄驹胶囊可更有效改善精子正常形态百分率,是治疗男性不育症的有效药物,但尚需进一步的大样本、高质量、多中心的随机对照的双盲临床试验。
Objective To observe the curative effect of compound xuanju capsule on infertility by Meta-analysis. Methods The Cochrane Library, Pubmed Database, Chinese Biomedical Literature Database, CNKI Database, VIP Database and Wanfang Database were searched. Randomized controlled trials (RCTs) were included in the treatment of infertility with Xuan Ju Si Capsule, and the methodological quality was evaluated. RevMan 5.3 software for statistical analysis, and published bias assessment and sensitivity analysis. Results Nine RCT articles were included in this study, with a total of 1199 cases. Meta analysis showed that compound Xuanju Capsules could improve and enhance the A-level sperm rate [WMD = 1.35,95% CI (-6.36,9.07), P = 0.73] Sperm density [WMD = 3.80, 95% CI (-4.23, 11.82), P = 0.35], sperm motility [WMD = -68.66, 95% CI (RR = 0.79, 95% CI 0.51, 1.23, P 0.30) and total effective rate [RR 0.86, 95% CI 0.70, 1.05, P 0. 01) P = 0.13], but was superior to the control group in improving the percentage of normal morphology [WMD = 9.00, 95% CI (0.59, 17.40), P = 0.04]. Conclusion Compound Xuanju Capsule can effectively improve the percentage of normal morphology of sperm. It is an effective drug for treating male infertility. However, a large sample, high quality and multicenter randomized controlled double-blind clinical trial is still needed.