论文部分内容阅读
目的 探讨选择性、非选择性内皮素(ET)受体拮抗剂对创伤性休克大鼠的影响。方法 采用后肢创伤法建立创伤性休克大鼠模型,随机分为休克组、休克+BQ-123组和休克+PD142893组,分别于创伤前、休克末、复苏后 1、3、5 h检测血浆内皮素及骨骼肌、肝脏、小肠的组织氧分压,监测血流动力学变化并记录存活时间。结果 3组大鼠休克末及复苏后备时间点血浆内皮素浓度及组织氧分压较伤前差异有显著性(P<0.05),休克+BQ-123组于复苏后 1、3 h血浆内皮素浓度显著低于休克组(P<0.05),复苏后肝脏、小肠的组织氧分压较休克组显著升高(P<0.05),其 12、24 h存活率同休克组比较差异均有显著性(P<0.05)。结论 创伤性休克后血浆内皮素浓度显著升高,选择性ETA受体拮抗剂BQ-123可显著改善创伤性休克大鼠内脏组织氧分压,延长存活时间。
Objective To investigate the effects of selective and non-selective endothelin (ET) receptor antagonists on traumatic shock rats. Methods A rat model of traumatic shock was established by hindlimb trauma. The rats were randomly divided into shock group, shock + BQ-123 group and shock + PD142893 group. The levels of plasma endothelium before and at the end of shock, Histone and skeletal muscle, liver, small intestine tissue oxygen partial pressure, hemodynamic changes were monitored and the survival time was recorded. Results The plasma endothelin concentrations and tissue oxygen partial pressure at the end of shock and resuscitation standby time in the three groups were significantly different from those before injury (P <0.05). The levels of plasma endothelin (P <0.05). Compared with the shock group, the partial pressure of oxygen in liver and small intestine increased significantly after resuscitation (P <0.05), and the difference between the 12 and 24 h survival rates was significant (P <0.05). Conclusions The plasma endothelin concentration is significantly increased after traumatic shock. The selective ETA receptor antagonist BQ-123 can significantly improve the oxygen partial pressure and prolong the survival time of visceral tissue in traumatic shock rats.