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目的探讨双歧杆菌四联活菌片对急性胰腺炎患者血清内毒素和降钙素原(PCT)水平的影响及疗效观察。方法将66例急性胰腺炎患者随机分为观察组和对照组。两组患者均予以禁食禁饮、持续胃肠减压、预防感染、抑酸、解痉镇痛、抑制胰酶分泌和纠正水电解质酸碱紊乱等常规治疗。观察组患者加用双歧杆菌四联活菌片1.5 g进行水化后自胃管灌注,夹管2 h,3次/d,对照组除不使用双歧杆菌四联活菌片外余治疗同观察组。观察两组患者治疗前后血清内毒素和PCT水平的变化,并比较其临床疗效。结果治疗7 d后,两组患者血清内毒素和PCT水平均有不同程度的下降(P<0.05或P<0.01),且观察组下降值比对照组更明显(P<0.05);同时观察组临床总有效率为93.94%,明显高于对照组的75.76%(χ2=4.24,P<0.05)。结论双歧杆菌四联活菌片辅助治疗急性胰腺炎具有较好疗效,能明显降低血清内毒素和PCT水平,减轻肠源性内毒素血症,对肠黏膜屏障功能具有良好的保护作用。
Objective To investigate the effect of Bifidobacterium quadriceps on the level of serum endotoxin and procalcitonin (PCT) in patients with acute pancreatitis and to observe its curative effect. Methods 66 patients with acute pancreatitis were randomly divided into observation group and control group. Both groups were given fasting forbidden drink, sustained gastrointestinal decompression, prevention of infection, acid suppression, antispasmodic analgesia, inhibition of pancreatic enzyme secretion and correction of water and electrolyte acid-base disorders and other conventional treatment. Patients in the observation group were given 1.5 g of live Bifidobacterium quadriceps, hydrated and then perfused with gastric tube for 2 h and 3 times per day. Patients in the control group were treated with non-Bifidobacterium quadriceps survivor Same observation group. The changes of serum endotoxin and PCT levels before and after treatment in both groups were observed, and their clinical effects were compared. Results Serum endotoxin and PCT levels in both groups decreased to some extent (P <0.05 or P <0.01) after 7 days of treatment, and the decrease in the observation group was more significant than that in the control group (P <0.05) The total clinical effective rate was 93.94%, which was significantly higher than that of the control group (χ2 = 4.24, P <0.05). Conclusions Bifidobacterium quadriceps can effectively treat acute pancreatitis, reduce serum endotoxin and PCT levels, relieve intestinal endotoxemia, and have good protective effect on intestinal mucosal barrier function.