在有机分子催化的不对称合成领域,手性有机酸催化和有机胺催化是其中两个非常重要的研究方向.羰基化合物的-烷基化反应是形成碳碳键的重要合成策略.手性有机胺催化羰基化合物的不对称-烷基化反应已经有较多的研究报道,但是手性有机酸催化的该类反应还很少见.多 Chiral organic acid catalysis and organic amine catalysis are two very important research directions in the field of asymmetric synthesis catalyzed by organic molecules. The alkylation of carbonyl compounds is an important synthesis strategy for the formation of carbon-carbon bonds. Chiral organic Amine-catalyzed asymmetric-alkylation of carbonyl compounds has been reported in more studies, however, such reactions catalyzed by chiral organic acids are rare