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目的:观察轻中度缺铁性贫血(IDA)伴反复呼吸道感染(RRI)儿童服用细菌溶解产物(泛福舒)的临床疗效及安全性。方法:采用随机法将68例轻中度IDA伴RRI患儿分为两组,A组35例,口服铁剂同时口服泛福舒,B组33例,仅口服铁剂治疗,观察两组患儿的临床症状、血清免疫球蛋白IgA、IgG、IgM和血红蛋白(HB)水平及可能出现的不良反应。结果:A组治疗后血清IgA、IgG及HB水平比治疗前显著升高(P<0.05或P<0.01),IgM与治疗前比较差异无统计学意义(P>0.05);B组治疗后IgA、IgG、IgM与治疗前比较差异均无统计学意义(P均>0.05),HB水平有所升高,但差异无统计学意义(P>0.05);与B组比较,A组呼吸道感染次数、发热天数、抗生素使用天数、咳嗽天数均减少,差异均有统计学意义(P<0.01或P<0.05)。结论:IDA合并RRI经口服铁剂治疗不理想儿童联用泛福舒能有效减少RRI的发生,较快纠正贫血。泛福舒安全性好,使用方便,值得推广。
Objective: To observe the clinical efficacy and safety of bacterial dissolution products (Pan Fu Shu) in children with mild to moderate iron deficiency anemia (IDA) and recurrent respiratory tract infections (RRI). Methods: A total of 68 mild to moderate IDA patients with RRI were randomly divided into two groups. Group A (n = 35) received oral iron simultaneously with Pan Fu Shu. Group B (n = 33) received oral iron therapy only. Children’s clinical symptoms, serum immunoglobulin IgA, IgG, IgM and hemoglobin (HB) levels and possible adverse reactions. Results: Serum levels of IgA, IgG and HB in group A were significantly higher than those before treatment (P <0.05 or P <0.01), but there was no significant difference in IgM between before and after treatment (P> 0.05) , IgG and IgM had no significant difference with those before treatment (all P> 0.05), while the level of HB increased, but the difference was not statistically significant (P> 0.05); Compared with group B, the number of respiratory tract infection in group A (P <0.01 or P <0.05). The days of fever, days of antibiotics and days of cough were all decreased. Conclusion: Combination of IDA and RRI with oral iron therapy is not good in children with panforte can effectively reduce the incidence of RRI, quickly correct anemia. Pan Fu Shu safety, easy to use, it is worth promoting.