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青霉素类抗生素可引起过敏性休克,过敏性皮疹及药物热等不良反应已为临床所熟知。但由青霉素类抗生素引起的神经系统毒性反应报道很少,我们在1例用氧哌嗪青霉素及氨苄青霉素治疗老年肺部感染的过程中发生了青霉素脑病,特此介绍。王△△(住院号367181),男,72岁,离休干部,因慢性支气管炎、肺气肿伴发肺部感染于1988年10月4日入院。2年前因咽部新生物,颈淋巴结肿大,经病理活检诊断“恶性淋巴瘤”,化疗后至今未复发。查体:体温36℃,脉搏l00次/分,呼吸28次/分,血压18.6/8kPa,慢性病容,神清,桶状胸,肺部叩诊高清音,
Penicillin antibiotics can cause allergic shock, allergic rash and drug fever and other adverse reactions are well-known in the clinic. However, penicillin antibiotics caused by the nervous system toxicity rarely reported, we in 1 case of piperacillin and ampicillin in the treatment of senile pulmonary infection occurred penicillin encephalopathy, hereby introduced. Wang △△ (hospital number 367,181), male, 72 years old, retired cadres, due to chronic bronchitis, emphysema associated with pulmonary infection was admitted on October 4, 1988. 2 years ago due to pharyngeal neoplasms, cervical lymph nodes, pathological biopsy diagnosis of “malignant lymphoma,” since the chemotherapy has not relapsed. Examination: body temperature 36 ℃, pulse l00 beats / min, breathing 28 beats / min, blood pressure 18.6 / 8kPa, chronic disease, Shen Qing, barrel chest, lung percussion high definition sound,