目的:探讨重症药疹(seve readverse drug reactions)的最佳治疗方案,提高救治成功率,减少并发症及药物不良反应.方法:回顾性分析我院2015年3月～2020年9月共24例重症药疹住院患者治疗的临床资料.按照治疗方案不同分成三组:第一组给予氢化可的松琥珀酸钠治疗;第二组给予甲泼尼龙联合地塞米松治疗;第三组给予甲泼尼龙联合地塞米松及血液灌流治疗.观察比较三组患者治疗1周后总有效率与不良反应.结果:第三组总有效率100％,与其他组间差异显著(P＜0.05),不良反应为17％,与第一组间“,”Objective:To explore the best treatment of severe drug eruption (seve readverse drug reactions),improve the success rate of treatment, reduce complications and adverse drug reactions. Method: The clinical data of 24 hospitalized patients with severe drug eruption in our hospital from March 2015 to September 2020 were retrospectively analyzed. They were divided into three groups according to different treatment regimens: The first group was treated with hydrocortisone sodium succinate; The second group was treated with methylprednisolone combined with dexamethasone; The third group was treated with methylprednisolone combined with dexamethasone and hemoperfusion. The total effective rate and adverse reactions were observed and compared among three groups after 1 week of treatment. Result: The total effective rate of the third group was 100％, which was significantly different from that of the other groups (P＜ 0.05), and the adverse reaction was 17％, which was significantly different from that of the first group (P＜0.05). Conclusions: Patients with severe drug eruption should be treated with adequate hormone in early stage, including methylprednisolone combined with dexamethasone and hemoperfusion, as well as strengthening supportive therapy and nursing, which can greatly reduce the mortality rate.