论文部分内容阅读
目的：检测ＮＭＤＡ受体拮抗剂ＤＬ２ａｍｉｎｏ５ｐｈｏｓｐｈｏｎｏｖａｌｅｒｉｃａｃｉｄ（ＡＰＶ）对福尔马林诱导的大鼠伤害性行为反应的镇痛效应。方法：在大鼠左足趾部ｓｃ福尔马林诱导化学损伤性行为反应，经蛛网膜下腔引入药物，观察对此行为反应的抑制效应。结果：ＡＰＶ剂量依赖地抑制福尔马林诱导的持续性伤害性行为反应并有时间作用特点；ＡＰＶ对其中的反射性缩腿反应也有抑制作用，但没有时间作用特点。结论：ＮＭＤＡ受体在脊髓痛觉传递和疼痛反应过程中起重要作用；但ＮＭＤＡ受体拮抗剂ＡＰＶ是否有直接的镇痛效应仍需进一步分析。
Objective: To detect the analgesic effect of NMDA receptor antagonist DL2aminophosphonovalericacid (APV) on nociceptive behavior induced by formalin in rats. METHODS: Sc-induced formalin-induced chemical damage was induced in the left toe of rats and the drug was introduced into the subarachnoid space to observe the inhibitory effect on this behavioral response. Results: APV dose-dependently inhibited formalin-induced persistent nociceptive behavior and had time-dependent characteristics. APV also inhibited reflexive shrunken reaction but had no time-effect characteristics. CONCLUSION: NMDA receptors play an important role in the process of spinal allotransmission and pain response. However, whether NMDA receptor antagonist APV has a direct analgesic effect needs further analysis.