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自噬(autophagy)是1个严谨调控的代谢途径.哺乳动物细胞通过自噬能够降解和循环利用大分子和某些细胞器.自噬作为一种适应的机制,保护有机体对抗各种病理病变,包括感染、癌症、退行性病变、衰老和心脏疾病等.在移除蛋白聚集体、以及受损或过剩细胞器时,自噬发挥着很关键的作用,从而能够维持细胞能量平衡并适应环境压力.当自噬不足或过剩时,自噬也可作为一种促死亡的机制.在不同的情况下,自噬活化的程度通过自噬信号通路网络而精确地调节.死亡相关蛋白激酶(DAPK)是1个刺激调节蛋白激酶,它由几个功能结构域组成.这些结构域能让它参与广泛的信号通路中,包括凋亡、自噬和膜泡.DAPK在调节自噬中发挥着关键的作用.本文综述了在不同的情况下DAPK负调控或是正调控自噬的路径.
Autophagy is a well-regulated metabolic pathway through which mammalian cells can degrade and recycle macromolecules and certain organelles.As a mechanism of adaptation, autophagy protects the organism against various pathological pathologies including Infections, cancers, degenerative diseases, aging and heart disease, etc. Autophagy plays a crucial role in removing protein aggregates, as well as damaged or excess organelles, thereby maintaining cellular energy balance and adapting to environmental stress. Autophagy may also serve as a mechanism of pro-death in autophagy when the autophagy is insufficient or excessive, and in different situations, the degree of autophagy activation is precisely regulated by the network of autophagy signaling pathway.Death-related protein kinase (DAPK) is 1 A family of stimulatory regulatory protein kinases, which consist of several functional domains that allow it to participate in a wide range of signaling pathways, including apoptosis, autophagy, and vesicles, and plays a crucial role in the regulation of autophagy. This article reviews the pathways in which DAPK negatively regulates or regulates autophagy under different circumstances.