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Dear Editor,rnNicotine is a psychoactive alkaloid that is thought to play a key role in addiction to commercial tobacco products [1] and cotinine is its primary metabolite [2].Pharmacological treatment,such as nicotine replacement therapy (NRT),is a valid solution to this problem.Tobacco smoke contains many carcinogens such as nitrosamines [i.e.,nicotinederived nitrosamine ketone (NNK) and N-nitrosonornicotine (NNN)],and nicotine undergoes chemical conversion into NNK and NNN during the processes of curing and smoking [3].