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目的 研究孤独症患儿的脑血流和细胞功能。方法 采用单光子发射计算机体层摄影术 ,对 31例符合中国精神疾病分类方案与诊断标准第 2版修订本中孤独症的诊断标准的患儿 (研究组 )和 2 0名排除神经精神科疾病、患躯体疾病的非孤独症儿童 (对照组 )进行脑影像分析。结果 (1)视觉定性分析 ,研究组中有 2 7例存在 36个放射性分布减低区 ,其中以左侧额叶 (13个 )和双侧颞叶(左右侧分别为 6个和 8个 )皮质较多见。 (2 )放射性计数分析 ,研究组左侧额叶 (84± 34 )和海马 (6 2±2 3)低于右侧 [分别为 (88± 32 )和 (6 7± 2 6 ) ],差异有非常显著性 (P <0 0 1) ;对照组各部位左右侧比较 ,差异均无显著性。结论 孤独症儿童左侧额叶、海马及双侧颞叶存在局部血流灌注降低和细胞功能障碍。
Objective To study cerebral blood flow and cell function in children with autism. Methods Single photon emission computed tomography (TPL) was performed in 31 children (study group) who met the diagnostic criteria for autism in the revised edition of the Chinese Mental Disease Classification Scheme and the Second Revision of Diagnostic Criteria, and 20 children with neuropsychiatric disorders , Non-autistic children suffering from somatic diseases (control group) were brain imaging analysis. Results (1) According to the qualitative analysis of vision, there were 27 cases of radioactive reduction in 27 cases in the study group. Among them, the left frontal lobe (13) and the bilateral temporal lobe (6 and 8 left and right, respectively) See more. (2) Radioactive count analysis showed that left frontal lobe (84 ± 34) and hippocampus (62 ± 23) in the study group were lower than those in the right [(88 ± 32) and (67 ± 26) There was significant difference (P <0.01). There was no significant difference in the left and right sides of the control group. Conclusion Autonomic children with left frontal lobe, hippocampus and bilateral temporal lobes have decreased local blood flow and cell dysfunction.