论文部分内容阅读
本文运用脉冲辐解探究了不同自由基与药物氟西汀(FLX)之间的反应。羟基自由基(?OH)与FLX反应生成苯环上的羟基加成物,而硫酸根阴离子自由基(SO_4?~-)则通过单电子氧化FLX生成苯阳离子自由基,该中间产物再进一步与水反应生成苯环上的羟基加成物。本研究测定了三种自由基?OH,水合电子(e_(aq)~-)以及SO_4?~-与FLX反应的反应速率常数分别为:7.8×10~9,2.3×10~9和1.1×10~9mol?L~(-1)?s~(-1)。本文还运用电子束辐照技术探究了不同辐照条件下的FLX降解效果,结合HPLC和紫外可见光谱仪进行分析。在N_2O和空气饱和的两种条件下,FLX溶液经1.5 k Gy辐照后降解效率均达到90%以上,而N_2饱和条件下,加入0.1 mol?L~(-1)的叔丁醇的FLX溶液经1.5 k Gy辐照后仅有43%分解。此外,酸性和中性条件下FLX的降解效率均大于碱性条件下的。结果阐明了饱和空气的FLX溶液在中性条件下的降解效果最佳,且?OH诱导的反应比SO_4?~-更有利于FLX的分解。本研究期望对于进一步探究FLX的降解反应提供有益的帮助。
In this paper, we explored the reaction between different free radicals and fluoxetine (FLX) by pulsed radiolysis. Hydroxyl radical (? OH) reacts with FLX to form hydroxyl adduct on benzene ring, and sulfate anion radical (SO4? - -) generates phenyl cation radical by single electron oxidation of FLX. The intermediate product is further reacted with Water reacts to form hydroxyl adducts on the benzene ring. In this study, the reaction rate constants for the reaction of three free radicals OH, e_ (aq) ~ ~ and SO_4 ~ ~ with FLX were determined as follows: 7.8 × 10 ~ 9,2.3 × 10 ~ 9 and 1.1 × 10 ~ 9mol? L ~ (-1)? S ~ (-1). In this paper, electron beam irradiation technology was also used to investigate the effect of FLX degradation under different irradiation conditions. The results of HPLC and UV-Vis spectroscopy were analyzed. Under the conditions of N 2 O and air saturation, the degradation efficiency of FLX solution reached more than 90% after being irradiated by 1.5 k Gy, while under N 2 saturation condition, 0.1 mol? L -1 tert-butanol FLX Only 43% of the solution decomposed after 1.5 k Gy irradiation. In addition, the degradation efficiency of FLX under both acidic and neutral conditions was higher than that under alkaline conditions. The results show that the FLX solution saturated air under the best degradation conditions in the neutral conditions, and? OH induced reaction than the SO_4 ~ ~ - more conducive to the decomposition of FLX. This study is expected to provide useful help for further exploring the degradation reaction of FLX.