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目的探讨交感皮肤反应(sympathetic skin response,SSR)在糖尿病自主神经病变诊断中的价值。方法对186例糖尿病周围神经病(Diabetic peripheral neuropathy,DPN)患者和203例糖尿病非DPN患者进行SSR检测,同时对102例健康人进行SSR检测。结果SSR起始潜伏期异常率高于波幅异常率,下肢的异常率高于上肢异常率。DPN患者中,174例(93.5%)SSR异常,其中32例未引出SSR,142例起始潜伏期延长,109例波幅下降。203例DM非DPN患者中,46例(22.7%)SSR起始潜伏期延长和/或波幅下降,其中19例有出汗异常,4例在检查后数月出现出汗异常。结论SSR是早期诊断糖尿病自主神经病变的敏感手段,可发现亚临床神经病,并与病情进展相吻合。
Objective To investigate the value of sympathetic skin response (SSR) in the diagnosis of diabetic autonomic neuropathy. Methods 186 cases of diabetic peripheral neuropathy (DPN) and 203 cases of non-diabetic patients with diabetes were detected by SSR, and 102 cases of healthy people SSR test. Results The abnormal rate of initial SSR latency was higher than that of amplitude abnormality, and the abnormal rate of lower limbs was higher than that of upper limbs. Among the DPN patients, 174 cases (93.5%) had abnormal SSR, of which 32 cases did not lead to SSR, the initial latency of 142 cases was prolonged, and the amplitude of 109 cases was decreased. Of the 203 DM non-DPN patients, 46 (22.7%) had an initial increase in latency and / or amplitude of SSR, of which 19 had sweating abnormalities and 4 had sweating abnormalities in the months following the examination. Conclusion SSR is a sensitive method for early diagnosis of diabetic autonomic neuropathy. It can be found in subclinical neuropathy and is consistent with the progression of the disease.