作者报告用由加里弗尼亚电鳐的发电组织提纯的乙酰胆碱受体(AChR)使恒河猴产生实验性自身免疫性重症肌无力。所获得的临床、药理电生理学、免疫学和组织学的结果与人的重症肌无力(MG)极为相似。用1％Triton×100(辛烷基-苯氧基聚乙氧基乙醇)溶解电鳐发电组织膜碎片,而后通过在Najanaja siamensis神经毒(一种蛇毒)-葡聚糖树脂上进行亲和性层析提纯。提纯的AChR的比活性为每毫克蛋 The authors report that rhesus monkeys develop experimental autoimmune myasthenia gravis using an acetylcholine receptor (AChR) purified from a tissue of the California electricity generation. The clinical, pharmacologic, immunological and histological findings obtained are very similar to those of human myasthenia gravis (MG). Tissue membrane fragments were generated by dissolving electroporation with 1% Triton x 100 (octyl-phenoxypolyethoxyethanol) followed by affinity on Najanaja siamensis neurotoxic (a venom) -glucan resin Chromatography purification. The specific activity of purified AChR is per milligram of egg