1967年日本Kawasaki首先报道,在东京红十字中心,于6年内发现50名婴幼儿曾患一种急性出疹性疾病,其特征为持续发热、粘膜充血、颈淋巴结肿大以及指甲周围脱皮等。本病临床表现和实验室检查结果,与其他粘膜皮肤综合征和儿童出疹性疾病不同,因而认为是一种新的疾病,并将其称之为粘膜皮肤淋巴结综合症(简称MCLS)。此后, In 1967, Kawasaki first reported that at the Tokyo Red Cross Center, 50 infants and young children were found to have had one acute rash disease in six years. They were characterized by persistent fever, mucosal congestion, enlarged cervical lymph nodes and peeling around the nails. The clinical manifestations and laboratory findings of this disease, unlike other mucocutaneous syndromes and childhood eruptions, are considered as a new disease and are referred to as mucocutaneous lymph node syndrome (MCLS). Since then,