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目的对国内外有关胎儿胼胝体发育不全预后情况的文献进行系统综述,探讨该病的临床结局及对比分析单纯性胼胝体发育不全与伴发其他畸形的发育不全预后情况,为该病产前咨询提供依据。方法运用Meta分析的方法综合分析国内外1990~2012年关于胼胝体发育不全患儿预后情况的文献报道。结果经筛选并纳入本次M eta分析的文献共15篇,累计病例565例。产前诊断胎儿胼胝体发育不全,引产率达65%;男性发病率大于女性,合并RR=1.29,95%CI=1.04~1.59,P<0.05,差异有统计学意义。单纯性胼胝体发育不全预后良好达70%;伴发其他畸形的胼胝体发育不全患儿预后良好者仅仅16%;伴发其他畸形的胼胝体发育不全明显比单纯性发育不全的患儿预后差,合并OR=0.07,95%CI=0.02~0.24,P<0.05,差异有统计学意义。结论产前影像学诊断胎儿胼胝体发育不全,其引产率较高。胼胝体发育不全中男性比例大于女性。单纯性较伴发畸形的胼胝体发育不全患儿预后较好,但是伴发其他畸形的胼胝体发育不全患儿预后不容乐观。
OBJECTIVE: To systematically review the literature about the prognosis of fetal corpus callosum at home and abroad, to explore the clinical outcome of the disease and to compare and analyze the prognosis of simple hypoplastic corpus callosum and other deformities. . Methods Meta-analysis was used to comprehensively analyze the literature about the prognosis of children with corpus callosum hypoplasia from 1990 to 2012 at home and abroad. Results A total of 15 articles were screened and included in this M eta analysis, with a total of 565 cases. Prenatal diagnosis of fetal corpus callosum hypoplasia, induction rate of 65%; male morbidity than women, the combined RR = 1.29, 95% CI = 1.04 ~ 1.59, P <0.05, the difference was statistically significant. Simple corpus callosum hypoplasia with a good prognosis of up to 70%; associated with other deformities of the corpus callosum hypoplasia in children with good prognosis was only 16%; associated with other malformations of the corpus callosum was significantly worse than simple hypoplasia in children with poor prognosis, OR = 0.07, 95% CI = 0.02 ~ 0.24, P <0.05, the difference was statistically significant. Conclusion Prenatal imaging diagnosis of fetal corpus callosum hypoplasia, the high rate of induction. The proportion of males in the corpus callosum is greater than in women. The prognosis is better in children with hypoplastic corpus callosum with congenital malformations, but the prognosis is not optimistic in children with hypoplastic corpus callosum associated with other malformations.