【摘 要】
：
Interleukin-18 (IL-18) was discovered as an interferon-γ-inducing factor and had a critical role in inflammatory and immune response. It stimulates natural kil
【机 构】
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Department of Life Science,These
【出 处】
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Cellular & Molecular Immunology
【基金项目】
：
Sookmyung Women’s University Research Grants
论文部分内容阅读
Interleukin-18 (IL-18) was discovered as an interferon-γ-inducing factor and had a critical role in inflammatory and immune response. It stimulates natural killer (NK) and T cells and enhances Th1 immune response. These activated immune cells eliminate cancer cells and virus-infected cells effectively. However, IL-18 has also been found to promote tumor progression. Higher expression or secretion level of IL-18 is detected in various cancer cells in comparison with normal control, and IL-18 is able to induce angiogenesis, migration/metastasis,proliferation and immune escape. These dual effects and the mechanism of IL-18 need to be investigated further as it relates to cancer.
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