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目的 研究风湿热（RF）患儿血清脂蛋白（a）[Lp（a）]和胆固醇（TC）变化的临床意义。方法 分别采用单克隆抗体ELISA法和酶法对RF患儿63例,正常对照组70例测定Lp（a）和TC水平。结果 RF患儿血清Lp（a）较正常对照组高,差异有显著性（P<0.01）,RF患儿各组间的Lp（a）差异无显著性（P均>0.05）,但均高于对照纽,差异均有显著性（P<0.05或P<0.01）。RF患儿血清TC较对照组低,差异有显著性（P<0.05）,而RF患儿各组间TC也均低于对照组,但差异均无显著性（P均>0.05）。结论 RF患儿TC下降机制尚来清楚。血清Lp（a）增高可作为RF患儿风湿活动的参考指标,而其持续增高可能是促使RF向风湿性心脏病发展的危险因素之一。
Objective To investigate the clinical significance of serum lipoprotein (a) [Lp (a)] and cholesterol (TC) in children with rheumatic fever (RF). Methods The levels of Lp (a) and TC in 63 children with RF and 70 normal controls were measured by ELISA and ELISA respectively. Results The serum level of Lp (a) in RF children was higher than that in normal controls (P <0.01). There was no significant difference in Lp (a) among all the groups (all P> 0.05) In control group, the difference was significant (P <0.05 or P <0.01). The serum TC of RF children was lower than that of the control group (P <0.05), while the TC of the RF children was lower than that of the control group, but the difference was not significant (all P> 0.05). Conclusion The mechanism of TC decline in RF children is still clear. The increase of serum Lp (a) may be used as a reference index of rheumatic activity in children with RF, and its continuous increase may be one of the risk factors to promote the development of RF to rheumatic heart disease.