目的探讨南阳市门诊和住院病人幽门螺杆菌(Helicobacter pylori,Hp)感染情况。方法采用电子胃镜检查时行胃黏膜活检,快速尿素酶试验检测1 950例患者Hp感染情况,并按性别、年龄、疾病种类等分类统计。结果共1 000例呈阳性,Hp感染率为51.28%;男性530例,Hp感染率为53.00%,女性470例,Hp感染率为47.00%;在20岁以下,20～、40～及60岁以上几个年龄段中,Hp感染率从60.87%上升至67.65%;常见消化道疾病中各种溃疡、残胃炎、残胃溃疡等Hp感染率高达70%以上,尤以复合性溃疡最高,达93.75%;慢性萎缩性胃炎以60岁以上发病率最高,达8.28%,胆汁反流性胃炎以20岁以下发病率最高,达45.65%,消化性溃疡随年龄增长发病率有上升趋势。结论Hp感染无性别差异;随年龄增长,Hp感染率逐渐升高,这一变化可能与年龄变化伴随的疾病谱变化有关;消化性溃疡(尤以复合性溃疡和多发性溃疡)Hp感染率高,而慢性浅表性胃炎Hp感染率最低。 Objective To investigate the prevalence of Helicobacter pylori (Hp) in outpatients and inpatients in Nanyang City. Methods The gastric mucosal biopsy and rapid urease test were used to detect the Hp infection in 1 950 cases by electronic gastroscopy and classified according to sex, age, disease type and so on. Results A total of 1 000 cases were positive and the infection rate of Hp was 51.28%. Among the 530 males, the prevalence of Hp infection was 53.00% and the number of females was 470. The prevalence of Hp infection was 47.00%. Under the age of 20, 20-40, and 60 Among the above several age groups, the infection rate of Hp increased from 60.87% to 67.65%. Hp infection rates of various ulcers, residual gastritis and residual gastric ulcer in common gastrointestinal diseases were as high as 70% or more, especially the highest in complex ulcers 93.75%. Chronic atrophic gastritis had the highest incidence over the age of 60, accounting for 8.28%. The incidence of bile reflux gastritis was the highest under 45 years, reaching 45.65%. The incidence of peptic ulcer increased with age. Conclusions There is no gender difference in Hp infection. With the increase of age, the infection rate of Hp gradually increases. This change may be related to the change of spectrum of disease accompanied by age variation. Hp infection rate of peptic ulcer (especially in complex ulcer and multiple ulcer) , While chronic superficial gastritis Hp infection rate is the lowest.