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为探讨血清胃泌素与大肠癌的关系及临床意义。采用放射免疫法测定50例大肠癌患者血清胃泌素水平。结果，术前血清胃泌素水平显著高于于对照组（P＜0．001），术后明显下降（P＜0．005）；血清胃泌素水平与大肠癌临床分期，病理类型相关，分期愈晚，分化愈差，水平愈高；术后复发转移组高于无复发转移组和对照组（P＜0．05）。认为测定血清胃泌素水平对大肠癌诊断、治疗及估计预后有临床意义。
To explore the relationship between serum gastrin and colorectal cancer and its clinical significance. Radioimmunoassay was used to measure serum gastrin levels in 50 patients with colorectal cancer. Results Preoperative serum gastrin levels were significantly higher than those in the control group (P<0.001) and significantly decreased after surgery (P<0.005). Serum gastrin levels were related to the clinical stage and pathological type of colorectal cancer. The later the staging, the worse the differentiation and the higher the level; the postoperative recurrence and metastasis group was higher than the relapse-free metastasis group and the control group (P<0.05). It is considered that the determination of serum gastrin levels has clinical significance in the diagnosis, treatment and prognosis of colorectal cancer.