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幽门螺杆菌(Hp)感染已遍布世界各地,它与一些重要疾病的发生包括胃、十二指肠溃疡病、慢性活动性胃炎、萎缩性胃炎、胃底腺癌、胃淋巴细胞增生性疾病如淋巴瘤等有密切相关。幽门螺杆菌感染在中国显示出比较高的流行率,中国成年人群的感染率近60％,与之相关的疾病亦很常见。在消化性溃疡及胃癌病人的Hp菌株中发现约40kb的DNA片断与Hp致病性有密切关系,其被命名为cag致病岛(pathogeniciry island),本文就有关Hpcag致病岛的情况作一综述。 1 cag致病岛的发现 1995年,Xiang等根据空泡毒素(VacA)和毒素相关基因A抗原(CagA)的表达与否将Hp分成Ⅰ型和Ⅱ型(VacA~-,CagA~-)。1996年,Censini等在研究Ⅰ型和Ⅱ型Hp菌株的遗传学差异与致病关系中发现Ⅰ型
Helicobacter pylori (Hp) infection has spread all over the world, with some important diseases including stomach, duodenal ulcer disease, chronic active gastritis, atrophic gastritis, gastric adenocarcinoma, gastric lymphoproliferative diseases such as Lymphoma, etc. are closely related. Helicobacter pylori infection shows a relatively high prevalence in China, with an infection rate of nearly 60% in China’s adult population, and the related diseases are also common. In the peptic ulcer and gastric cancer patients Hp strains found about 40kb DNA fragment and Hp pathogenicity is closely related to its named cag pathogenic island (pathogeniciry island), this article on the Hpcag pathogenic island made a Summary. In 1995, Xiang et al. Classified Hp into type I and type II (VacA ~ -, CagA ~ -) based on the expression of vacuolar toxin (AIV) and toxin-related antigen A (CagA). In 1996, Censini et al. Found that in studying the genetic differences between type I and type II Hp strains and the pathogenicity, Type I