越来越多的临床研究发现,糖尿病患者会出现认知功能减退,甚至早在空腹血糖受损或糖耐量受损时。随着糖尿病病程的进展,认知功能减退也会愈来愈明显,并逐渐发展为痴呆。明确糖尿病患者出现认知功能减退的相关危险因素,从而早期干预其发展以防止发病,减轻患者及其家庭的负担,这已成为当代医生的一大使命。本文重点就目前研究所知的糖尿病患者认知功能减退与遗传因素、糖尿病病情和合并症的关系进行综述。 More and more clinical studies have found that patients with diabetes will have cognitive decline, even as early as impaired fasting glucose or impaired glucose tolerance. With the progress of diabetes, cognitive decline will be more obvious, and gradually develop into dementia. Identifying the relevant risk factors for cognitive decline in people with diabetes and thereby intervening early in their development to prevent morbidity and reduce the burden on patients and their families has become a major mission of contemporary doctors. This article focuses on the current study of diabetic patients with cognitive dysfunction and genetic factors, the relationship between diabetes and comorbidities were reviewed.