舒马曲普坦(sumatriptan)鼻粉剂(Onzetra xsail)是5-羟色胺衍生物1B/1D受体激动剂,作用于脑内血管和三叉神经感觉神经,使血管收缩,抑制炎症前神经多肽释放,用于治疗有或无预兆的偏头痛。用气动输送装置鼻孔内递送该药,每次22 mg,每个鼻孔给予11 mg,24 h内最多用2次,间隔至少2 h。FDA批准是根据 Sumatriptan Nasal Powder (Onzetra xsail) is a serotonin derivative 1B / 1D receptor agonist that acts on the brain and trigeminal sensory nerves, causing vasoconstriction, inhibiting the release of proinflammatory polypeptide, Used to treat migraine with or without warning. The drug is delivered nostril in a pneumatic delivery device at 22 mg each and given 11 mg per nostril, up to 2 times within 24 h, with an interval of at least 2 h. FDA approval is based on