继脑啡肽和β-内啡肽的发现之后,Goldstein等于1979年发现了另一种以亮啡肽为N末端的内源性阿片样物质——强啡肽。这种十七肽广泛分布于中枢神经系统,尤以下丘脑和脊髓为著。在离体豚鼠迴肠标本上,强啡肽的作用较亮啡肽强700倍,较去甲吗啡强190倍。但注入脑内并无明确的镇痛作用,其生 Following the discovery of enkephalins and beta-endorphins, Goldstein et al. Found in 1979 that another endogenous opioid, dynorphin, with leupeptin as its N-terminal end. This heptadecapeptide is widely distributed in the central nervous system, especially in the hypothalamus and spinal cord. In vitro guinea pig ileum specimens, the role of dynorphin stronger than the bright nucleotides 700 times, 190 times stronger than normorphine. But injected into the brain and no clear analgesic effect, its students