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目的:研究妊娠晚期低甲状腺素(T4)血症的妊娠结局,探讨2012年中华医学会《妊娠及产后甲状腺疾病诊治指南》和2011年美国甲状腺学会(American thyriod association,ATA)《妊娠及产后甲状腺疾病诊治指南》对妊娠晚期低T4血症临床应用的合理性。方法:回顾性分析2014-09~2015-12住院分娩的妊娠晚期低T4血症患者58例为病例组,甲功正常妊娠晚期妇女56例为对照组。收集所有研究对象的甲状腺功能测定指标水平,包括促甲状腺激素(TSH)、游离三碘甲状腺素原氨酸(FT3)、三碘甲状腺素原氨酸(T3)、T4、游离甲状腺素(FT4)及其妊娠结局、妊娠期并发症、新生儿结局。结果:病例组FT3、FT4、T3、T4均较对照组明显降低(P<0.05),TSH两组比较无统计学差异(P>0.05)。与对照组相比,病例组BMI水平明显升高(P<0.05)。两组妊娠结局、妊娠期并发症及母婴结局无统计学差异。结论:妊娠晚期低T4血症患者较妊娠晚期甲功正常妇女相比,妊娠结局发生率相同。
Objective: To investigate the pregnancy outcome of hypothyroidism (T4) in the third trimester of pregnancy and to explore the diagnostic criteria of diagnosis and treatment of thyroid disease in pregnancy and postpartum in 2012 and the thyroid in the American thyroid association (ATA) Disease diagnosis and treatment guidelines "on the late pregnancy low T4 blood disease clinical rationality. Methods: A retrospective analysis of 58 cases of late pregnancy-induced hypo-T4 hyperlipidemia during hospital delivery from 2014-09 to 2015-12 was taken as case group. 56 cases of normal thyroid function in the third trimester of pregnancy were used as the control group. Thyroid function parameters, including thyroid stimulating hormone (TSH), free triiodothyronine (FT3), triiodothyronine (T3), T4, free thyroxine (FT4) And its pregnancy outcome, complications during pregnancy, neonatal outcome. Results: The FT3, FT4, T3 and T4 in the case group were significantly lower than those in the control group (P <0.05). There was no significant difference between the two groups (P> 0.05). Compared with the control group, the BMI level in the case group was significantly higher (P <0.05). Two groups of pregnancy outcomes, complications during pregnancy and maternal and infant outcomes no significant difference. CONCLUSIONS: The incidence of pregnancy outcomes was the same in patients with late-stage T4 hypoalgesemia compared with those with normal early-stage thyroid function in the third trimester of pregnancy.