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据Belgardt BF 2015年6月20日[Nat Med,2015,21(6):619-627.]报道,小RNA(microRNA-200家族)与胰岛B细胞的存活和糖尿病的形成存在着很大关联。在人体和动物中,充足的胰岛素分泌能够保证血液中葡萄糖浓度维持在正常的生理范围。在2型糖尿病的发病过程中,胰岛素分泌慢慢减少,直至胰岛B细胞完全死亡然后胰岛素分泌终止。胰腺中的胰岛B细胞缺失是1型和2型糖尿病的标志性事件,然而背后的机制还不清晰。
According to Belgardt BF, June 20, 2015 [Nat Med, 2015, 21 (6): 619-627.] It is reported that small RNAs (microRNA-200 family) are associated with the survival of islet B cells and the formation of diabetes . In humans and animals, adequate insulin secretion to ensure that the concentration of glucose in the blood to maintain the normal physiological range. During the onset of type 2 diabetes, insulin secretion slowly decreases until pancreatic B cells die completely and insulin secretion ceases. Pancreatic islet B cell loss is a hallmark of type 1 and type 2 diabetes, yet the underlying mechanism remains unclear.