目的研究新药盐酸川丁特罗进入大鼠体内后经独特的代谢途径生成特殊代谢产物的合成方法。方法以4-氨基-3-三氟甲基苯甲酸为起始原料,经氯代、甲基化、碘代、甲磺酰基化、溴代、还原、胺化得到目标化合物。结果经7步反应合成目标化合物,总收率为3%,目标化合物结构经1 H-NMR和MS确证。结论该化合物为盐酸川丁特罗代谢物研究提供物质支持。 OBJECTIVE To study the synthesis of a new metabolite of chondrotol hydrochloride, which is produced by a unique metabolic pathway, into rats. Methods Starting from 4-amino-3-trifluoromethylbenzoic acid, the target compound was obtained by chlorination, methylation, iodination, mesylation, bromination, reduction and amination. Results The target compounds were synthesized in 7 steps with a total yield of 3%. The structures of target compounds were confirmed by 1 H-NMR and MS. Conclusion This compound provides material support for the study of chondrotol hydrochloride metabolites.