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本文以水杨酸为对照测定了小檗碱对常见致病真菌的体外抗真菌活性。发现其对深部真菌的MIC范围为31.25～125mg/L,对皮肤癣菌的MIC范围为62.5～250mg/L。同时发现该药的MIC明显低于水杨酸。扫描和透射电镜观察也证实经该药处理后石膏毛癣菌,申克孢子丝菌、疣状着色霉菌出现菌外形改变及菌细胞破坏。
In this paper, salicylic acid as a control berberine in vitro fungal activity of common pathogenic fungi. It was found that the MIC range for deep fungi 31.25 ~ 125mg / L, the MIC range of dermatophytes 62.5 ~ 250mg / L. Also found that the drug’s MIC was significantly lower than salicylic acid. Scanning and transmission electron microscopy also confirmed that the treatment of the drug Trichophyton mentagrophytes, Scirocco sp., Verrucous coliform bacteria appearance change and bacterial cell destruction.