多组分串联反应能从简单原料实现复杂目标化合物的快速、高效合成,最大限度地提高了反应效率.本文研究了重氮化合物、醇以及邻炔基芳醛的三组分串联反应,通过Rh2(OAc)4与AuCl3协同催化,成功实现了单催化策略不能发生的反应,一步高效构建了多官能团异色烯骨架并且反应有较好的化学选择性和中等至较好的非对映选择性. The multicomponent tandem reaction can realize the rapid and efficient synthesis of complex target compounds from simple raw materials and maximize the reaction efficiency.In this paper, the three-component tandem reaction of diazo compounds, alcohols and orthoalkynyl aryl aldehydes was studied by Rh2 (OAc) 4 co-catalyzed with AuCl3 successfully achieved a single catalytic strategy can not react, one step efficient construction of multi-functional isochromate skeleton and the reaction has good chemical selectivity and moderate to good diastereoselectivity .