论文部分内容阅读
目的:探讨肝硬变患者血清肿瘤坏死因子(TNFα)、白细胞介素6(IL-6)、层粘连蛋白(LN)、Ⅳ型胶原含量变化及其在肝纤维化中的临床意义。方法:取空腹静脉血,采用酶联免疫法测定血清TNFα、IL-6、LN、Ⅳ型胶原。结果:肝硬变患者血清TNFα、IL-6、LN、Ⅳ型胶原含量升高,与对照组比较有显著性差异(P<0.05),TNFα、IL-6含量与LN、Ⅳ型胶原含量呈正相关。结论:肝纤维化过程中,贮脂细胞的活化,胶原合成增加与TNFα、IL-6等细胞因子的作用有关。
Objective: To investigate the changes of serum tumor necrosis factor (TNFα), interleukin 6 (IL-6), laminin (LN) and collagen Ⅳ in patients with liver cirrhosis and their clinical significance in liver fibrosis. Methods: Fasting venous blood was taken and serum TNFα, IL-6, LN and type Ⅳ collagen were measured by enzyme-linked immunosorbent assay. Results: The serum levels of TNFα, IL-6, LN and type Ⅳ collagen in patients with cirrhosis increased significantly compared with those in the control group (P <0.05). The levels of TNFα and IL-6 in serum of patients with cirrhosis were positively correlated Related. Conclusion: During the process of hepatic fibrosis, the activation of lipid-storing cells and the increase of collagen synthesis are related to the effects of cytokines such as TNFα and IL-6.