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目的:探讨2型糖尿病患者对磺脲类药物继发失效后的治疗方法。方法:将对磺脲类药物继发失效的2型糖尿病患者133例,分为短效中混合(7:3)胰岛素联合二甲双胍或拜糖平组:胰岛素联合文迪亚组;磺脲类联合中效胰岛素及二甲双胍或拜糖平组;诺和龙联合二甲双胍组;诺和龙联合文迪亚5个组。观察空腹血糖(FPG)、餐后2小时血糖(2hPG)、糖化血红蛋白(HbAic)、体质指数(BMI)、胰岛素抵抗指数(HOMA-IR)、胰岛素B细胞功能指数(HOMA-B)的改变。结果:各组的观察指标均有明显改善,其中以用预混胰岛素加文迪亚组改善最为显著。
Objective: To investigate the treatment of type 2 diabetes patients after secondary failure of sulfonylureas. Methods: A total of 133 type 2 diabetic patients with secondary failure of sulfonylureas were divided into three groups: short-acting mixed (7: 3) insulin plus metformin or albuterol group Middle-acting insulin and metformin or orally administered group; Novo-longan and metformin group; Novo-longand the combination of Wendia 5 groups. The changes of fasting blood glucose (FPG), 2hPG, HbAic, BMI, HOMA-IR and HOMA-B were observed. Results: The observation indexes in each group were significantly improved, among which the improvement was most obvious with the premixed insulin plus plus-dendron group.