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增生性玻璃体视网膜病变 (PVR)是裂孔源性视网膜脱离手术失败最常见的原因。研究结果表明 ,PVR是视网膜脱离手术后的创伤愈合反应。随着视网膜的创伤 ,活化的视网膜色素上皮细胞 ,胶质细胞 ,纤维母细胞等增殖、迁移 ,与细胞外间质共同形成了PVR膜而导致牵引性视网膜脱离。就PVR的治疗而言 ,早期在于控制炎症 ,中期主要是抑制细胞增殖 ,晚期着重于防止纤维化的形成。着重就PVR的危险因素、临床分类、病理、手术处理以及最新的药物治疗进展做综合归纳。
Proliferative vitreoretinopathy (PVR) is the most common cause of failed rhegmatogenous retinal detachment surgery. The results show that PVR is a wound healing reaction after retinal detachment surgery. With the trauma of the retina, the activated retinal pigment epithelial cells, glial cells, fibroblasts and other proliferation, migration, together with the extracellular matrix formation of PVR membrane lead to traction retinal detachment. In terms of the treatment of PVR, the early stage is to control inflammation, the middle stage is mainly to inhibit cell proliferation, late focus on preventing the formation of fibrosis. Focus on the risk factors of PVR, clinical classification, pathology, surgical treatment and the latest progress of drug treatment to do a comprehensive summary.