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[目的]研究2型糖尿病(DM)合并腹泻患者肠道菌群及胃肠动力变化,探讨2型DM腹泻的发病机制。[方法]通过大便特检、消化道钡餐及纤维结肠镜检查研究60例2型DM合并腹泻患者的肠道菌群、胃肠动力及肠黏膜变化,并与40例无腹泻的2型DM患者对照。[结果]与对照组比较,2型DM腹泻患者血糖水平更高(P<0.01),无明显肠道菌群失调,但有脂肪吸收不良(P<0.01),且胃肠动力明显紊乱。[结论]2型DM腹泻患者存在胃肠动力紊乱,可能与高血糖、糖尿病植物神经病变有关。
[Objective] To study the intestinal flora and gastrointestinal motility in patients with type 2 diabetes mellitus (DM) complicated with diarrhea and to explore the pathogenesis of type 2 DM diarrhea. [Methods] Intestinal flora, gastrointestinal motility and intestinal mucosal changes in 60 patients with type 2 DM complicated with diarrhea were studied by special inspection of stool, barium meal and colonoscopy of digestive tract, and compared with 40 patients with type 2 DM without diarrhea Control. [Results] Compared with the control group, type 2 DM diarrhea patients had higher blood glucose level (P <0.01), no obvious intestinal flora dysfunction, but poor fat absorption (P <0.01), and gastrointestinal motility was significantly disturbed. [Conclusion] Gastrointestinal motility disorder exists in patients with type 2 DM diarrhea, which may be related to hyperglycemia and diabetic autonomic neuropathy.