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目的本研究旨在观察临床药学服务对于儿童支气管哮喘的改善情况。方法进行了一项随机双盲对照研究,比较传统发药模式和临床药学服务模式的影响。90例支气管哮喘患儿入组,年龄在2~12 a,经临床医生确诊为支气管哮喘后,随机分为传统发药模式组和临床药学服务模式组,主要观察2组患儿不同时间点用药依从性、就诊次数和例数以及哮喘控制情况。结果传统发药模式组中依从性评分量表中≥30分在1个月、3个月和6个月分别为31%、29%和33%;相比药学服务组达到了76%(P=0.002)、85%(P=0.000 1)和94%(P=0.000 2)。药物服务组患儿的就诊次数和例数都明显降低,特别是7~12个月,与传统发药模式比有明显的统计学差异(P=0.002;P=0.024);在哮喘控制上,儿童哮喘控制测试量表显示,传统发药模式组中评分≥30分的患者比例在1~3个月内为27%,4~6个月为31%,7~12个月为30%;相比药学服务模式组达到了53%(P=0.028)、82%(P=0.001)和92%(P=0.0002)。临床医生和简易肺功能检测中,传统发药模式组中完全控制的患儿比例、1、3和6个月分别为53%、66%和65%,相比药学服务组分别为70%(P=0.020),85%(P=0.026)和90%(P=0.005)。结论在儿童支气管哮喘中开展药学服务,有助于改善患儿的病情,使哮喘得到较好的控制,这一服务模式可以长期开展,以此降低和控制儿童支气管哮喘的发病。
Purpose This study aimed to observe the improvement of clinical pharmacy services in children with bronchial asthma. Methods A randomized, double-blind, controlled study was conducted to compare the impact of traditional drug delivery patterns and clinical pharmacy service models. 90 cases of children with bronchial asthma into the group, aged 2 to 12 years, diagnosed as bronchial asthma by a clinician, were randomly divided into traditional drug delivery model group and clinical pharmacy service model group, the main observation of two groups of children at different time points Compliance, attendance and number of cases, and asthma control. Results In the conventional drug delivery model group, the compliance scale score was ≥30 at 31, 29 and 33% at 1 month, 3 and 6 months, respectively, compared to 76% in the pharmacy service group (P = 0.002), 85% (P = 0.0001) and 94% (P = 0.0002). The number of patients and the number of cases treated in the drug service group decreased significantly, especially in the period of 7 to 12 months (P = 0.002; P = 0.024). In asthma control, The Childhood Asthma Control Test Scale showed that the proportion of patients with a score ≥30 in the traditional drug delivery group was 27% in 1-3 months, 31% in 4-6 months and 30% in 7-12 months; 53% (P = 0.028), 82% (P = 0.001) and 92% (P = 0.0002) compared to the pharmacy service model group. Among clinicians and simple pulmonary function tests, the proportion of children with complete control in the traditional drug delivery group was 53%, 66%, and 65% at 1, 3, and 6 months, respectively, compared to 70% P = 0.020), 85% (P = 0.026) and 90% (P = 0.005). Conclusion The development of pharmacy services in children with bronchial asthma helps to improve the condition of children and control the asthma. This service mode can be implemented for a long time to reduce and control the incidence of bronchial asthma in children.