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目的检测宫颈上皮内瘤变(CIN)及浸润性鳞状细胞癌中CK8、CK17的表达,并探讨其病理意义。方法应用免疫组化MaxVision法检测宫颈上皮内瘤变(CIN)44例(Ⅰ级20例,Ⅱ、Ⅲ级24例)、浸润性鳞状细胞癌25例和正常宫颈组织20例中的CK8、CK17的表达情况。结果正常对照组鳞状上皮CK8、CK17均为(-);浸润性鳞状细胞癌的阳性率分别为88%和92%,其表达均以中等强度及强阳性为主;CIN高级别组的阳性率分别为58.3%和58.3%,以中等强度为主;CIN低级别组的阳性率分别为10%和30%,其均以弱及中等强度为主。结论 CK8、CK17的阳性表达率及程度与宫颈鳞状细胞病变的严重程度密切相关。CK8、CK17在宫颈癌变过程中起到重要作用。
Objective To detect the expression of CK8 and CK17 in cervical intraepithelial neoplasia (CIN) and invasive squamous cell carcinoma (SCC), and to explore its pathological significance. Methods Immunohistochemical MaxVision method was used to detect the expression of CK8, CIN in 44 cases (20 cases of grade Ⅰ, 24 cases of grade Ⅱ and Ⅲ), 25 cases of invasive squamous cell carcinoma and 20 cases of normal cervical tissue. CK17 expression. Results The positive rates of CK8 and CK17 in normal squamous epithelium were (-). The positive rates of invasive squamous cell carcinoma were 88% and 92%, respectively. The positive rates were 58.3% and 58.3%, respectively, with a moderate intensity. The positive rates of CIN low-grade group were 10% and 30%, respectively, which were mainly weak and moderate. Conclusion The positive rate and degree of CK8 and CK17 are closely related to the severity of cervical squamous cell lesions. CK8, CK17 play an important role in cervical carcinogenesis.