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目的探讨代偿期肝硬化患者肝组织质量与肝血流动力学、可溶性细胞间粘附分子1含量的关系。方法分别用彩超、放射免疫法及病理HE染色法检查100例代偿期肝硬化患者,研究肝组织质量与肝血流动力学、肝纤维化指标及病理分期的关系。结果肝硬化患者肝质量越重,病理肝纤维化程度越明显,并随着肝质量的增加,肝血流减少;肝硬化患者肝组织不同质量的透明质酸(HA)、Ⅲ型前胶原(HPCⅢ)和血清Ⅳ型胶原(CⅣ)含量明显高于正常对照组(P<0.05);肝组织质量越重,血清HA、HPCⅢ和CⅣ含量越高;肝硬化患者肝组织质量与血清肝纤维化程度呈正相关(r=0.5612,P<0.05)。结论肝硬化患者肝组织质量与肝血流动力学、肝纤维化指标及病理分期有关。
Objective To investigate the relationship between liver tissue quality and hepatic hemodynamics and soluble intercellular adhesion molecule-1 in patients with compensated cirrhosis. Methods 100 patients with decompensated cirrhosis were examined by color Doppler ultrasonography, radioimmunoassay and pathological HE staining. The relationship between liver tissue quality and hepatic hemodynamics, liver fibrosis indexes and pathological staging were studied. Results The liver mass of patients with liver cirrhosis was more severe and the degree of pathological liver fibrosis was more obvious. With the increase of liver mass, the hepatic blood flow decreased. The content of hyaluronic acid (HA), type Ⅲ procollagen HPCⅢ) and serum type Ⅳ collagen (CⅣ) in liver cirrhosis were significantly higher than those in normal control group (P <0.05). The more severe the liver tissue was, the higher the serum HA, HPCⅢ and CⅣ levels were. The degree was positively correlated (r = 0.5612, P <0.05). Conclusions The liver tissue quality of patients with cirrhosis is related to hepatic hemodynamics, liver fibrosis indexes and pathological staging.