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目的:研究芍药苷的经皮渗透性,并考察透皮渗透促进剂氮酮(azone)对经皮渗透性的影响。方法:以Wistar大鼠为实验动物,采用经皮微渗析技术进行经皮渗透性研究。以浓差法测定探针的体外回收率,以反向渗析法测定探针的在体回收率。结果:氮酮可以显著提高药物透过性,1%,3%,5%azone经皮传递率分别为0.906 9,1.887 8,1.272 8μg.h-1。结论:azone是芍药苷经皮吸收优良的渗透促进剂,且促渗效果与浓度不成线性。经皮微渗析技术是在体研究药物经皮渗透性的有效手段。
OBJECTIVE: To study the percutaneous permeability of paeoniflorin and investigate the effect of transdermal penetration enhancer azone on the transdermal permeability. Methods: Wistar rats were used as experimental animals, and percutaneous microdialysis technique was used to study the transdermal permeability. The concentration recovery method was used to determine the recovery rate of the probe in vitro, and the reverse recovery method was used to determine the recovery rate of the probe in vivo. Results: Azone could significantly improve the drug permeability. The transdermal delivery rates of 1%, 3% and 5% azone were 0.906 9, 1.887 8 and 1.272 8 μg.h -1, respectively. CONCLUSION: azone is an excellent permeation enhancer for percutaneous absorption of paeoniflorin, and the effect of promoting penetration is not linear with the concentration. Percutaneous microdialysis technique is an effective method to study the transdermal drug penetration in vivo.